The Queen's College of Guyana (originally Queen's College Grammar School for Boys) was founded in 1844 by the Most Reverend William Piercy Austin, D.D., Bishop of British Guiana (now Guyana).
Although the School started out as an Anglican [Episcopal] Church School, Bishop Austin was interested in making it a more broad-based institution to include non-Anglicans. Its first administration, however, consisted only of members of the Church of England.
Formal classes commenced on August 15, 1844 in the Old Colony House (located in the compound of what is now the Guyana High Courts - the previous Victoria Law Courts). The original fifteen students had two tutors, with Bishop Austin himself becoming the first Principal. In 1845, the School moved to Main and Quamina (then Murray) Streets.
In 1876, the School became a "Colonial Institution" and was renamed Queen's College. Several more moves took the School to the site of the present Ministry of Health Building (Vlissengen road and Brickdam) in 1918 and then to its present location in Thomas Lands (Camp and Thomas Roads), where the facilities were formally opened on December 3, 1951.